The Trusted Lab's CBG Gummies offer an innovative approach to promote overall and especially gastrointestinal health. See what CBG's all about! Taking CBD for gut health is a new approach in how we can properly take care of our digestive tract. How does it work? Is it effective? Read more. News portal for UAMS
Happy Tummy CBG Gummy 750mg
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Try out The Trusted Lab’s NEW Happy Tummy CBG Gummy.
The Trusted Lab’s New Happy Tummy CBG Gummies are infused with the highest quality CBG and contain ZERO THC. This formula serves multiple areas of health, including brain, gut, and inflammation. Each Happy Tummy Gummy includes 25 milligrams of CBG and is excellent to take on any day!
As more and more research is solidified about CBG, our products will continue to be a source of high-quality, pure CBG that you can count on.
For more information on CBG and its properties, read US Patent A6630507.
*Please note we cannot issue any refunds, returns, or exchanges on the Share and Save boxes.
CBG is a new and innovative method to support multiple areas of health, especially gastrointestinal health.
Yummy Tummy CBG Gummy
- Made with 100% natural registered hemp product.
- Highest quality CBG concentrate.
- Gummy Ingredients: Organic glucose syrup (wheat), organic cane sugar, pectin, citric acid, ascorbic acid, natural flavors, natural colors (organic concentrated apple, organic carrot, organic pumpkin, organic black currant), industrial hemp.
- Organic Glucose Syrup does not contain gluten and registers as Gluten Free.
- Contains: 25 milligrams CBG per gummy
- High absorption and bio-availability.
- ZERO THC.
- Purity tested.
- Free of harsh metals, pesticides, and harmful solvents, GMOs, Parabens, Phthalates, and artificial coloring.
- Made in the USA.
How To Use
Take 1-2 gummies with food as needed.
- When to use: When needed .
- How Often: Daily .
- Absorption: Allow 15 minutes for maximum absorption.
- Always listen to how your body feels and adjust accordingly.
100% THC COMPLIANT
This product has been lab-tested for compliance and safety, and it is either THC Free or does not contain more than 0.3% THC, depending on your selection.
Taking CBD for Gut Health: Is It Effective?
Over 2,000 years ago, the father of modern medicine, Hippocrates, stated that “all disease begins in the gut.” And we’ve all heard the old saying, “you are what you eat.” Modern science is discovering there is more than a kernel of truth in these statements. Of all the things to try, does taking CBD for gut health actually work?
When you take some time to think about all of the things that happen in the gastrointestinal (GI) system, you will soon realize that the GI system does more than just digest food. How good or bad your digestive health is can affect many other body systems.
When digestive problems such as Crohn’s disease, leaky gut syndrome, and other GI disorders occur, it is time to look for ways to remedy them. While some look at conventional methods, others are looking at alternatives like CBD oil.
But, does CBD oil help with digestive health?
TL;DR – There are a few ways that using cannabinoids, like CBD, can help your gut out. One of the most important things it can do is help manage unwanted inflammation.
Your Gut Microbiome is Important
Let’s explore how CBD oil may aid the digestive system and help with gastrointestinal disorders. As always, check with a healthcare professional before you use medical cannabis, CBD, or any other type of supplement to help treat a medical condition.
To understand gut health and the health benefits of CBD, we must first look at the gut microbiome. This interesting part of our body is a collection of trillions of bacteria, viruses, and fungi that share a harmonious space inside the body.
This microbiome performs many functions, but a few key ones are digestion of your food and nutrient absorption. Aside from this, it also produces the most neurotransmitters used by the body. Plus, the gut microbiome also regulates cognitive and physiological processes daily, including regulating the immune system.
If your gut microbiota remains in balance, all other systems will also work correctly. However, many significant health problems can occur once gut integrity goes out of balance (called dysbiosis). This is one of the reasons it is essential to maintain gut health.
The importance of a healthy digestive system means you’ll also have a healthy body with healthy systems like your heart. Heart disease is an area of concern in the US, and many suffer from the hardening of the arteries.
Having good gut health reduces the chances of having heart disease. By increasing your HDL cholesterol, you can achieve better gut health, and your risk of cardiovascular disease decreases. But there are many more reasons to have good gut health.
Some of the other things that happen when poor gut health is present are:
- An increase in bad bacteria resulting in obesity
- Risk of heart attack or stroke
- Possible development of type 2 diabetes
- Risk of high cholesterol
When bad bacteria is present from poor gut health, substances like triethylamine N-oxide (or TMAO) may block a person’s arteries and cause a stroke. One study demonstrated that good gut health helped prevent coronary artery disease.
Having a healthy gut helps the physical human body, but it also helps with mental health and a properly functioning central nervous system. Information is transmitted from the brain to the gut and back again via the vagus nerve.
Having good bacteria in the gut produces serotonin. Serotonin is one of the most important neurotransmitters that affect mental health. When this bacteria becomes imbalanced, depression and anxiety may occur.
This is why many are studying the effects of using CBD oil for gut health.
The Benefits of CBD and THC
THC and CBD are both found in all parts of cannabis plants. From the cannabis flowers to the stems, leaves, buds, and more. THC (Tetrahydrocannabinol) is a cannabinoid that produces a high feeling most commonly associated with medical marijuana use.
CBD (Cannabidiol) has more therapeutic benefits such as treating inflammatory bowel diseases, chronic pain, improving memory and brain functions.
CBD and the cannabis plant share some common traits with endocannabinoids. The endocannabinoid system is part of the human body. This system produces what are called “endocannabinoids.” These endocannabinoids act similarly to cannabinoids found in CBD products, medical cannabis, or recreational marijuana.
The Endocannabinoid System
CBD and endocannabinoids interact with the endocannabinoid system. It helps the body with digestive issues, inflammatory responses, pain relief, and more. CBD also helps by inhibiting the breakdown of the body’s neurotransmitters.
When this happens, the endocannabinoid system can function more effectively. This helps avoid the potential for a clinical endocannabinoid deficiency in the body.
Another thing that makes CBD and THC different is how they work with the CB1 and CB2 receptors. While THC binds directly to these receptors, CBD binds with these receptors indirectly.
CBD also prevents the enzyme FAAH from breaking down anandamide. Anandamide is an endocannabinoid neurotransmitter that helps regulate sleep, mood, memory, appetite, and digestion.
CBD’s ability to aid digestion is what scientists are interested in exploring using CBD oils further to help with digestive tract issues.
Using CBD Oil for Gut Health
If you are interested in taking CBD for gut health, consult a healthcare professional first.
CBD may interact with prescription medications, and a doctor will know if it is safe for you to take CBD as part of your daily routine or if you can combine it with prescription drugs.
CBD isolate is considered to be a form of pure CBD. This means that there is nothing in a CBD isolate product except CBD. No other cannabinoids are present, including the psychoactive THC. Plus, these products contain no flavonoids or terpenes.
A full-spectrum CBD product is just that. Full of everything the cannabis plant has to offer. It contains CBD, THC (an amount no higher than the legal 0.3%), terpenes, and flavonoids. Many users claim that full-spectrum provides the most complete CBD experience.
Broad-spectrum is very similar to full-spectrum. It contains CBD, flavonoids, terpenes, and even THC. The main difference between broad-spectrum and full-spectrum is that broad-spectrum contains only a trace amount of THC rather than the legal amount of 0.3% THC.
When looking for high-quality CBD products, look for a company that offers only organic, all-natural ingredients like organic hemp and MCT oil. New Phase Blends provides that and a whole lot more.
Our products are third-party lab-tested which means our potency and purity are available for the customer to see. We also offer a COA (Certificate Of Analysis), where customers can find all information about the product they purchase. This is an important thing to look for when buying CBD.
The Endocannabinoid System (ECS)
The endocannabinoid system (or ECS) is a natural part of the human body. It aids the body with several various functions such as immunity, sleep, brain function, pain, memory, metabolism, food intake, and digestion.
It binds CBD with the CB1 and CB2 receptors (cannabinoid receptors) to do all of these functions. CB1 receptors are found primarily in the central nervous system and in the brain.
At the same time, CB2 receptors can be found mainly in the large and small intestines and the immune system.
This means that the ECS’s primary function is to maintain a sense of balance in the human body providing optimal health. When CBD is introduced to this system, it acts as an aid to help get the system back on track and balanced to perform these functions properly.
CBD and Gut Health
When we consider how the body’s natural endocannabinoids assist and regulate the body’s systems, it seems only natural that CBD can also help when the endocannabinoid system becomes unbalanced.
Gut health and the digestive tract are some of the systems CBD can help support when the ECS is out of balance.
Since most health problems begin in the gut, it makes sense that this system needs support so that a ripple effect doesn’t occur and other systems such as digestion and mood don’t become unbalanced.
There are two main factors that CBD affects – Inflammation and the immune system.
How CBD Interacts with the Gut
When it comes to bacterial cells, the number residing within the gut is ten times the number of human cells within the body. The bacteria within the gut play an integral part in maintaining the health of the digestive tract.
The right kind of bacteria, and in the right numbers, are required to maintain the integrity of the immune system, reduce levels of inflammation, and promote positive mental well-being. Therefore, when gut health is compromised, issues are more likely to occur.
CBD is currently being researched for its potential benefits on gut health. A study conducted in 2019 demonstrated that rats who were suffering inflammation of the brain responded well when given CBD.
The researchers set out to test whether there was a link between the gut microbiome of the rats and the inflammation of the brain that they were experiencing and if administering CBD would help relieve the symptoms.
The result was that the CBD caused levels of a particular bacteria within the gut, Akkermansia muciniphila, to be lowered, resulting in reduced intestinal inflammation within the rats. This indicates that there does appear to be a link between CBD and improvements in gut health.
If you have problems with your digestive system, inflammation is most likely caused by inflammatory bowel disease or intestinal inflammation. When inflammation is present, it can cause all sorts of issues like stomach pain, lack of absorption, and diarrhea.
Some research shows that CBD (cannabidiol) reduces intestinal inflammation. For example, CBD can be used to help a stomach digest capsaicin by decreasing the sensitivity of the capsaicin receptor of the stomach.
This receptor indicates and triggers inflammation from the hot pepper in the mucous membrane of the stomach. The result is that burning sensation we all feel when eating spicy food. You reduce the abdominal pain associated with hot and spicy foods by taking CBD.
Taking hemp-derived CBD products or medical cannabis for gut health also helps improve the processes of the immune system that come from the gastrointestinal tract. Some studies indicate that taking cannabis oil helps improve the interaction between the immune system and gut bacteria.
When dysbiosis of the gut happens, the immune system becomes hyperactive. A hyperactive immune system begins to generate inflammation and, if left untreated, could result in Crohn’s disease symptoms.
Studies have shown that taking a CBD dosage reduces the hyperactive immune response, improving gut health and the immune system’s ability to handle toxins and allergens.
Reduction of Stress
Many CBD users already claim the stress-reducing benefits of CBD. Reducing stress is also crucial for optimal gut health. Who hasn’t heard someone say “my stomach is in knots” when they feel stressed or anxious?
Stress dramatically restricts the movement of digestion, especially intestinal motility (or how food makes its way through the digestive tract to be eliminated). It can also create problems with gut bacteria and the potential for gut permeability (leaky gut or intestinal permeability).
Studies also show that taking cannabidiol helps restore intestinal barrier dysfunction.
Adrenal Fatigue and Stress Responses
In today’s world, stress can come at all angles. When a person is under a lot of pressure, cortisol levels are elevated. This creates a bunch of problems with heart rate and digestion, but also the adrenal glands also become overburdened, and over time adrenal fatigue can occur.
Cortisol is a stress-fighting hormone produced in the body that comes into play when fighting an illness, inflammation, or dealing with a stressful experience. If these stresses continue, they’ll develop into a chronic disease, and adrenal fatigue will happen.
Adrenal Fatigue Syndrome (AFS) is difficult to diagnose as the symptoms are too vague for conventional lab tests. However, if the symptoms go untreated, it could lead to several physical problems, including digestive problems like gut inflammation.
Studies have shown that taking CBD may help reduce stress. Which also helps reduce the pressures placed on the adrenal glands, allowing the body systems, including digestion, to perform much more efficiently.
Can Taking CBD for Gut Health Affect Your Inflammation Circuit?
The neuroendocrine system helps the hypothalamus maintain homeostasis in the body. It is vital for regulating reproduction, metabolism, eating, drinking, energy utilization, and blood pressure. The inflammation circuit of this system activates almost immediately when stress affects your body.
This means that the three organs of this circuit, the immune system, gut microbiota, and the gut, are affected almost immediately. As this circuit goes through a period of dysfunction, the single layer of cells that make up the gut lining becomes compromised, and gut permeability may happen.
Stress affects the stomach lining making those tight junctions between cells looser. When this happens, undigested particles of food, viruses, bacteria, and fungi enter the bloodstream breaking havoc on your system.
The immune system goes into high gear as these foreign substances enter the bloodstream because it sees them as a threat. The result is increased inflammation as the system tries to locate the substances and destroy them.
If not treated, the immune system can become hyperactive to defend itself from these substances that escape the gut barrier. This may create autoimmune conditions and chronic illnesses. Everything related to the gut goes into overdrive.
The microbiome is affected by an imbalance in bacteria leading to ailments like:
- Bacteria overgrowth of the small intestines (or SIBO)
- Leaky Gut Syndrome
- and Crohn’s disease
1) Leaky Gut Syndrome
The healthy bacteria within the gut work to promote digestive health by upholding the integrity of the gut lining. When the balance of bacteria becomes compromised, bad bacteria begin to take control. Whenever this happens, an inflammatory response occurs, resulting in the lining of the gut becoming more permeable, and the passing of harmful bacteria through the cell walls can occur.
This is what’s known as leaky gut syndrome, which is linked to digestive disorders such as irritable bowel and inflammatory bowel disease.
Leaky gut can result in diarrhea, constipation, joint pain, skin disease, as well as headaches, and fatigue. Studies demonstrate that CBD promotes better health to the intestinal wall and improves the balance of bacteria within the digestive tract.
2) Irritable Bowel Syndrome
Irritable bowel syndrome is a digestive disorder that typically takes place in the large intestine. Common symptoms include increased gas, bloating, constipation, pain, or diarrhea. Some people can even experience all of these symptoms, making it a very uncomfortable disorder.
They can also occur as a result of many factors, such as eating certain foods, hormonal imbalances, or compromised mental well-being.
Although there hasn’t been much research looking into the look between CBD and irritable bowel syndrome, those we do have suggest that using CBD for gut health does result in a positive effect, particularly the use of CBD oil.
3) Crohn’s Disease
Crohn’s disease is a very serious autoimmune disorder occurring within the gut. It involves immune cells interacting with healthy bacteria within the digestive tract, mistaking them for foreign pathogens.
Pioneering UAMS Study Warns of CBD Supplements’ Harm to Gut Health
June 4, 2020 | LITTLE ROCK – Researchers at the University of Arkansas for Medical Sciences (UAMS) and the University of Mississippi are warning in the first study of its kind that CBD supplements in high doses can be harmful to the gut microbiome.
The study, “Potential Probiotic or Trigger of Gut Inflammation – the Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract,” is published in the Journal of Dietary Supplements.
While sales of cannabidiol (CBD) have skyrocketed, little is known about its potential side effects, said UAMS’ Igor Koturbash, M.D., Ph.D., the study’s senior author and principal investigator.
CBD is extracted from hemp (Cannabis sativa), which was removed from the federal list of controlled substances in 2018. The research team found that when taken orally, CBD disrupts the gut microbiome of mice and can damage the inner lining of the digestive tract, known as the gut mucosa.
“Cannabidiol significantly affects the gut microbiome, which in turn may affect the mucosa,” said Koturbash, associate professor in the College of Public Health, Department of Environmental and Occupational Health, and co-director of the Center for Dietary Supplements Research. “In low doses, it may potentially improve gut health as a probiotic, but in high doses it can cause leaky gut syndrome.”
Leaky gut syndrome is characterized by gaps in the intestinal walls that allow bacteria and other toxins into the bloodstream. It has serious health consequences and can be fatal.
Koturbash said the study’s findings point to the need for clinical trials to determine the safest, most effective CBD dosages for people.
The study involved a dozen researchers – nine from UAMS and three from the University of Mississippi. It drew expertise from several disciplines in the UAMS College of Public Health and the College of Medicine departments of Internal Medicine, Biomedical Informatics, Pharmacology and Toxicology, Pathology, and Pediatrics.
Among the changes in the gut, researchers observed multiple pro-inflammatory responses to CBD in the colon tissue. In addition, there were significant decreases in a gene that is closely associated with gut integrity.
“Taken together, these findings raise concerns about the safety of long-term CBD usage and underline the need for additional well-designed studies into its tolerability and efficacy,” the study concludes.
Other UAMS authors on the study are:
- Charles M. Skinner, B.S., senior research associate at the Center for Dietary Supplements Research, College of Public Health, Department of Environmental and Occupational Health. , Ph.D., associate professor in the College of Medicine Department of Biomedical Informatics
- Laura E. Ewing, M.Sc., a Ph.D. student at the College of Medicine Department of Pharmacology and Toxicology , Ph.D., instructor in the College of Medicine Department of Biomedical Informatics , Ph.D., instructor in the College of Medicine Department of Biomedical Informatics , M.D., associate professor in the College of Medicine Department of Pathology , M.D., assistant professor in the College of Medicine Department of Pathology , Ph.D., assistant professor in the College of Medicine Department of Pediatrics at the USDA-ARS-Arkansas Children’s Nutrition Center (ACNC), at Arkansas Children’s Hospital
University of Mississippi authors on the study are:
- Mahmoud A. ElSohly, Ph.D., research professor at The National Center for Natural Products Research, and Professor of Pharmaceutics and Drug Delivery, School of Pharmacy, and director of the National Institute on Drug Abuse (NIDA) Marijuana Project at the University of Mississippi
- Larry A. Walker, Ph.D., director emeritus of the National Center for Natural Products Research at the University of Mississippi.
- Bill J. Gurley, Ph.D., a principal scientist at the National Center for Natural Products Research at the University of Mississippi, Oxford.
The study was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant numbers 1P20GM109005 and P20GM125503; the National Institute of General Medical Sciences grant number T32GM106999; Clinical and Translational Science Awards UL1TR000039 and KL2TR000063; and the Arkansas Biosciences Institute.